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While you are taking Clopidogrel, do not take Plavix if you have ever had a stomach ulcer or bleeding in the digestive tract, make sure the doctor is aware of it because Plavix should be used with caution. Do not take aspirin, ibuprofen or naproxen without your doctor's advice. Patients receiving Clopidogrel. Clopidogrel should be used carefully if you suffer from problems inside the eyes, have bleeding problems due to severe liver disease, or expect to be at risk of bleeding from any other cause. Clopidogrel keeps the platelets in your blood from clotting to prevent unwanted blood clots that can block arteries. The sudden blockage of arteries that can lead to heart attack. Plavix has proved so safe and effective in patients who have already had a heart attack or stroke in certain groups of people at high risk for these events. Be used with caution.